Molecular imaging of NAD+ -dependent deacetylase SIRT1 in the brain.
Xu Y, Chen Z, Wey HY, Liang Y, Tanzi RE, Zhang C, Wang C.
Alzheimers Dement. 2021 Apr 15. PMID: 33860595
Shared intrinsic functional connectivity alterations as a familial risk marker for ADHD: a resting-state functional magnetic resonance imaging study with sibling design.
Chiang HL, Tseng WI, Wey HY, Gau SS.
Psychol Med. 2020 Oct 13:1-10. PMID: 33046145
Molecular imaging of Alzheimer’s disease-related gamma-secretase in mice and nonhuman primates.
Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C.
J Exp Med. 2020 Dec 7;217(12):e20182266. PMID: 32936886
Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging.
Deng X, Zhang Y, Chen Z, Kumata K, Van R, Rong J, Shao T, Hatori A, Mori W, Yu Q, Hu K, Fujinaga M, Wey HY, Shao Y, Josephson L, Murtas G, Pollegioni L, Zhang MR, Liang S.
Bioorg Med Chem Lett. 2020 Aug 15;30(16):127326. PMID: 32631531
Classics in Neuroimaging: Imaging the Endocannabinoid Pathway with PET.
Varlow C, Boileau I, Wey HY, Liang SH, Vasdev N.
ACS Chem Neurosci. 2020 Jul 1;11(13):1855-1862. PMID: 32559067
Advances in simultaneous PET/MR for imaging neuroreceptor function.
Sander CY, Hansen HD, Wey HY.
J Cereb Blood Flow Metab. 2020 Jun;40(6):1148-1166. PMID: 32169011
A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging.
Bai P, Bai S, Placzek MS, Lu X, Fiedler SA, Ntaganda B, Wey HY, Wang C.
Molecules. 2020 Feb 25;25(5):1018. PMID: 32106419
Associations between cerebral blood flow and structural and functional brain imaging measures in individuals with neuropsychologically defined mild cognitive impairment.
Kim CM, Alvarado RL, Stephens K, Wey HY, Wang DJJ, Leritz EC, Salat DH.
Neurobiol Aging. 2020 Feb;86:64-74. PMID: 31813626
Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.
Bai P, Wey HY, Patnaik D, Lu X, Lan Y, Rokka J, Stephanie F, Haggarty SJ, Wang C.
Chem Commun (Camb). 2019 Oct 24;55(86):12932-12935. PMID: 31599282
A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model.
Nie B, Wang L, Hu Y, Liang S, Tan Z, Chai P, Tang Y, Shang J, Pan Z, Zhao X, Zhang X, Gong J, Zheng C, Xu H, Wey HY, Liang SH, Shan B.
Neuroimage. 2019 Dec;203:116163. PMID: 31494249
Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson’s Disease.
Chen Z, Shao T, Gao W, Fu H, Collier TL, Rong J, Deng X, Yu Q, Zhang X, Davenport AT, Daunais JB, Wey HY, Shao Y, Josephson L, Qiu WW, Liang S.
ChemMedChem. 2019 Sep 4;14(17):1580-1585. PMID: 31365783
Neuroepigenetic signatures of age and sex in the living human brain.
Gilbert TM, Zürcher NR, Catanese MC, Tseng CJ, Di Biase MA, Lyall AE, Hightower BG, Parmar AJ, Bhanot A, Wu CJ, Hibert ML, Kim M, Mahmood U, Stufflebeam SM, Schroeder FA, Wang C, Roffman JL, Holt DJ, Greve DN, Pasternak O, Kubicki M, Wey HY, Hooker JM.
Nat Commun. 2019 Jul 3;10(1):2945. PMID: 31270332
PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.
Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM.
J Clin Invest. 2019 Jan 2;129(1):364-372. PMID: 30530989
Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging.
Placzek MS, Schroeder FA, Che T, Wey HY, Neelamegam R, Wang C, Roth BL, Hooker JM.
ACS Chem Neurosci. 2019 Jan 16;10(1):384-395. PMID: 30212182
A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism.
Gale EM, Wey HY, Ramsay I, Yen YF, Sosnovik DE, Caravan P.
Radiology. 2018 Mar;286(3):865-872. PMID: 29117483
Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A.
Van de Bittner GC, Van de Bittner KC, Wey HY, Rowe W, Dharanipragada R, Ying X, Hurst W, Giovanni A, Alving K, Gupta A, Hoekman J, Hooker JM.
ACS Chem Neurosci. 2018 Feb 21;9(2):358-368. PMID: 29035509
Effects of flow changes on radiotracer binding: Simultaneous measurement of neuroreceptor binding and cerebral blood flow modulation.
Sander CY, Mandeville JB, Wey HY, Catana C, Hooker JM, Rosen BR.
J Cereb Blood Flow Metab. 2019 Jan;39(1):131-146. PMID: 28816571
Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.).
Kochunov P, Wey HY, Fox PT, Lancaster JL, Davis MD, Wang DJ, Lin AL, Bastarrachea RA, Andrade MC, Mattern V, Frost P, Higgins PB, Comuzzie AG, Voruganti VS.
Front Neurosci. 2017 Feb 14;11:49. PMID: 28261040
Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine.
Hooker JM, Strebl MG, Schroeder FA, Wey HY, Ambardekar AV, McKinsey TA, Schoenberger M.
Sci Rep. 2017 Feb 16;7:42136. PMID: 28205593
Nasal neuron PET imaging quantifies neuron generation and degeneration.
Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O’Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM.
J Clin Invest. 2017 Feb 1;127(2):681-694. PMID: 28112682
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.
Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M.
Nat Commun. 2017 Jan 16;8:14064. PMID: 28091604
Insights into neuroepigenetics through human histone deacetylase PET imaging.
Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM.
Sci Transl Med. 2016 Aug 10;8(351):351ra106. PMID: 27510902
A regularized full reference tissue model for PET neuroreceptor mapping.
Mandeville JB, Sander CYM, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR.
Neuroimage. 2016 Oct 1;139:405-414. PMID: 27364474
PET Neurochemical Imaging Modes.
Placzek MS, Zhao W, Wey HY, Morin TM, Hooker JM.
Semin Nucl Med. 2016 Jan;46(1):20-7. PMID: 26687854
Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance.
Strebl MG, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM.
ACS Chem Neurosci. 2016 May 18;7(5):528-33. PMID: 26675505
The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients.
Chen X, Spaeth RB, Freeman SG, Scarborough DM, Hashmi JA, Wey HY, Egorova N, Vangel M, Mao J, Wasan AD, Edwards RR, Gollub RL, Kong J.
Mol Pain. 2015 Oct 29;11:67. PMID: 26511911
Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.
Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM.
Neuropsychopharmacology. 2015 Dec;40(13):2865-72. PMID: 26058662
Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain.
Wey HY, Wang C, Schroeder FA, Logan J, Price JC, Hooker JM.
ACS Chem Neurosci. 2015 May 20;6(5):708-15. PMID: 25768025
In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.
Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reis S, Kim SW, Holson EB, Haggarty SJ, Hooker JM.
J Med Chem. 2014 Oct 9;57(19):7999-8009. PMID: 25203558
Simultaneous fMRI-PET of the opioidergic pain system in human brain.
Wey HY, Catana C, Hooker JM, Dougherty DD, Knudsen GM, Wang DJ, Chonde DB, Rosen BR, Gollub RL, Kong J.
Neuroimage. 2014 Nov 15;102 Pt 2(0 2):275-82. PMID: 25107855
PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates.
Rotstein BH, Wey HY, Shoup TM, Wilson AA, Liang SH, Hooker JM, Vasdev N.
Mol Pharm. 2014 Nov 3;11(11):3832-8. PMID: 25004399
Dynamic functional imaging of brain glucose utilization using fPET-FDG.
Villien M, Wey HY, Mandeville JB, Catana C, Polimeni JR, Sander CY, Zürcher NR, Chonde DB, Fowler JS, Rosen BR, Hooker JM.
Neuroimage. 2014 Oct 15;100:192-9. PMID: 24936683
Synthesis and imaging validation of [¹⁸F]MDL100907 enabled by Ni-mediated fluorination.
Ren H, Wey HY, Strebl M, Neelamegam R, Ritter T, Hooker JM.
ACS Chem Neurosci. 2014 Jul 16;5(7):611-5. PMID: 24845956
A review of current imaging methods used in stroke research.
Wey HY, Desai VR, Duong TQ.
Neurol Res. 2013 Dec;35(10):1092-102. PMID: 24070268
S1 is associated with chronic low back pain: a functional and structural MRI study.
Kong J, Spaeth RB, Wey HY, Cheetham A, Cook AH, Jensen K, Tan Y, Liu H, Wang D, Loggia ML, Napadow V, Smoller JW, Wasan AD, Gollub RL.
Mol Pain. 2013 Aug 21;9:43. PMID: 23965184
Multi-region hemispheric specialization differentiates human from nonhuman primate brain function.
Wey HY, Phillips KA, McKay DR, Laird AR, Kochunov P, Davis MD, Glahn DC, Blangero J, Duong TQ, Fox PT.
Brain Struct Funct. 2014 Nov;219(6):2187-94. PMID: 23928747
Functional connectivity of the frontoparietal network predicts cognitive modulation of pain.
Kong J, Jensen K, Loiotile R, Cheetham A, Wey HY, Tan Y, Rosen B, Smoller JW, Kaptchuk TJ, Gollub RL.
Pain. 2013 Mar;154(3):459-467. PMID: 23352757
Multimodal MRI of nonhuman primate stroke.
Wey HY, Duong TQ.
Transl Stroke Res. 2012 Mar;3(1):84-9. PMID: 24323756
MRI of perfusion-diffusion mismatch in non-human primate (baboon) stroke: a preliminary report.
Wey HY, Kroma GM, Li J, Leland MM, Jones L, Duong TQ.
Open Neuroimag J. 2011;5:147-52. PMID: 22253656
Functional neuroimaging of the baboon during concurrent image-guided transcranial magnetic stimulation.
Salinas FS, Szabó CÁ, Zhang W, Jones L, Leland MM, Wey HY, Duong TQ, Fox PT, Narayana S.
Neuroimage. 2011 Aug 15;57(4):1393-401. PMID: 21664276
Anatomical, blood oxygenation level-dependent, and blood flow MRI of nonhuman primate (baboon) retina.
Zhang Y, Wey HY, San Emeterio Nateras O, Peng Q, De La Garza BH, Duong TQ.
Magn Reson Med. 2011 Aug;66(2):546-54. PMID: 21360746
Striatal and cortical BOLD, blood flow, blood volume, oxygen consumption, and glucose consumption changes in noxious forepaw electrical stimulation.
Shih YY, Wey HY, De La Garza BH, Duong TQ.
J Cereb Blood Flow Metab. 2011 Mar;31(3):832-41. PMID: 20940730
Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of visual and vibrotactile stimulations in baboons.
Wey HY, Wang DJ, Duong TQ.
J Cereb Blood Flow Metab. 2011 Feb;31(2):715-24. PMID: 20827260
Fetal brain during a binge drinking episode: a dynamic susceptibility contrast MRI fetal brain perfusion study.
Kochunov P, Castro C, Davis DM, Dudley D, Wey HY, Purdy D, Fox PT, Simerly C, Schatten G.
Neuroreport. 2010 Jul 14;21(10):716-21. PMID: 20505549
BOLD fMRI of visual and somatosensory-motor stimulations in baboons.
Wey HY, Li J, Szabó CA, Fox PT, Leland MM, Jones L, Duong TQ.
Neuroimage. 2010 Oct 1;52(4):1420-7. PMID: 20471483