Publications

1.        Sander SY, Hansen HD, Wey HY*. Advances in simultaneous PET/MRI for measuring neuroreceptor function. J. Cereb. Blood Flow Metab. (2020) [Epub ahead of print]

 

2.        Zürcher NR, Loggia ML, Mullett JE, Tseng CE, Bhanot A, Richey L, Hightower B, Wu C, Parmar AJ, Butterfield RI, Dubois JM, Chonde D, Izquierdo-Garcia D, Wey HY, Catana C, Hadjikhani N, McDougle CJ, Hooker JM. [11C]PBR28 MR-PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism. Mol. Psych. (2020) [Epub ahead of print]

 

3.        Bai P, Bai S, Placzek MS, Lu X, Fiedler SA, Ntaganda B, Wey HY, Wang C. A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging. Molecules (2020) [Epub ahead of print]

 

4.        Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson K, Bernales D, Koegel R, Fiedler S, Striar R, Wagner S, Tanzi R, Zhang C. Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and non-human primates. J. Exp. Med. 2020 (Accepted)

 

5.        Kim CM, Alvarado R, Stephens K, Wey HY, Wang DJ, Leritz EC, Salat DH. Associations between cerebral blood flow and structural and functional brain imaging measures in individuals with neuropsychologically defined mild cognitive impairment. Neurobiology of Aging. (Accepted)

 

6.        Bai P, Wey HY, Patnaik D, Fiedler S, Bai S, Haggarty SJ, Wang C. Positron Emission Tomography Probes Targeting Bromodomain and Extra-Terminal (BET) Domains to Enable In Vivo Neuroepigenetic Imaging. Chem. Comm. (Accepted)

 

7.        Chen Z, Shao T, Gao W, Fu H, Collier TL, Rong J, Deng X, Yu Q, Zhang X, Davenport AT, Daunais JB, Wey HY, Shao Y, Josephson L, Qiu WW, Liang S. Synthesis and preliminary evaluation of [11C]GNE-1023 as a novel potent PET probe for imaging leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. ChemMedChem. 2019. [Epub ahead of print]

 

8.        Nie B, Wang L, Hu Y, Liang S, Tan Z, Chai P, Tang Y, Shang J, Pan Z, Zhao X, Zhang X, Gong J, Zheng C, Xu H, Wey HY, Liang SH, Shan B. A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model. NeuroImage. 2019 (accepted)

 

9.        Gilbert TM†, Zürcher NR†, Catanese MC, Di Biase M, Lyall AE, Hightower BG, Bhanot A, Wu CJ, Hibert ML, Mahmood U, Stufflebeam SM, Schroeder FA, Wang C, Roffman JL, Pasternak O, Kubicki M, Wey HY, Hooker JM. Neuroepigenetics regulates age- and sex-specific phenotypes in the living human brain. Nature Communications. (2019) 10:2945. PMCID: PMC6610136.

 

10.    Gilbert TM, Zürcher NR, Zhao WN, Chindavong PS, Wu CJ, Bhanot A, Hightower BG, Riley MM, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini A, Wang C, Stufflebeam SM, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Haggarty SJ, Hooker JM. Neuroepigenetic imaging reveals dysregulation in schizophrenia. J. Clin. Invest. (2019) 129:364-372. PMCID: PMC6307962.

 

11.    Placzek MS, Schroeder FA, Che T, Wey HY, Neelamegam R, Wang C, Roth BL, Hooker JM. Discrepancies in kappa opioid agonist binding revealed through PET imaging. ACS Chem Neurosci. (2019) 10:384-395.

 

12.    Gale EM, Wey HY, Ramsay I, Sosnovik DE, Caravan P. A. Manganese-Based Alternative to Gadolinium: Contrast Enhanced MR Angiography, Pharmacokinetics, and Metabolism. Radiology. (2018) 286:865-872. PMCID: PMC5831267.

 

13.    Van de Bittner GC, Van de Bittner Kyle, Wey HY, Rowe W, Dharanipragada R, Ying X, Hurst W, Giovanni A, Alving K, Gupta A, Hoekman J, Hooker JM. Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A. ACS Chem. Neurosci. (2017) 9:358-368.

 

14.    Sander CY, Mandeville JB, Wey HY, Hooker JM, Catana C, Rosen BR. Effects of flow changes on D2/D3 radiotracer dynamics. In revision in J. Cereb. Blood Flow Metab. (2017) [Epub ahead of print]

 

15.    Kochunov P, Wey HY, Fox PT, Lancaster JL, Davis MD, Wang DJ, Lin AL, Bastarrachea RA, Andrade MCR, Frost P, Higgins PB, Mattern V, Comuzzie AG, Voruganti VS. Changes in cerebral blood flow during an alteration in glycemic state in a large non-human primate (Papio hamadryas Sp.). Frontiers in Neuroscience. (2017) 11:49. PMCID: PMC5306336.

 

16.    Hooker JM, Strebl MG, Schroeder FA, Wey HY, Ambardekar AV, McKinsey TA, Schoenberger M. Imaging cardiac SCN51 using the novel F-18 radiotracer radiocaine. Scientific Reports. (2017) 7:42136. PMCID: PMC5311962.

 

17.    Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O’Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM. PET Quantification of Nasal Neuron Generation and Early Degeneration in Aging and Disease. J. Clin. Invest. (2017) 127(2):681-694. PMCID: PMC5272198.

 

18.    Keliher E, Ye Y, Wojtkiewicz GR, Aguirre AD, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Tricot B, Sun Y, Courties G, Iwamoto Y, Wang C, Chen J, Swirski FK, Wey HY, Hooker JM, Fayad Z, Mulder WJM, Weissleder R, Nahrendorf M. Polyglucose nanoparticles with rapid renal elimination and high macrophage avidity for PET imaging in ischemic heart disease. Nat. Commun. (2017) 8:14064. PMCID: PMC5241815

 

19.    Wey HY, Gilbert TM, Zurcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Insights into Neuroepigenetics through Human Histone Deacetylase Imaging. Sci. Trans. Med. (2016) 8:351-.

 

20.    Mandeville JB, Sander CY, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. Simultaneous A regularized full reference tissue model for PET functional neuroreceptor mapping. NeuroImage. (2016) 139:405-414. PMCID: PMC5192005.

 

21.    Placzek MS, Zhao W, Wey HY, Morin TM, Hooker JM. PET Neurochemical Imaging Modes. Semi. Nucl. Med. (2016) 46:20-7.

 

22.    Strebl M, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM. Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. ACS Chem. Neurosci. (2016) 7:528-533.

 

23.    Chen X, Spaeth RB, Freeman SG, Scarborough DM, Hashmi JA, Wey HY, Egorova N, Vangel M, Mao J, Wasan AD, Edwards RR, Gollub RL, Kong J. The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients. Mol Pain (2015) 11:67-. PMCID: PMC4625557.

 

24.    Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM. Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored in vivo with PET.  Neuropsychopharmacology (2015) 40:2865-72. PMCID: PMC4864638.

 

25.    Wey HY, Wang C, Schroeder FA, Logan J, Price JC, Hooker JM. Kinetic Analysis and Quantification of [11C]Martinostat for In vivo HDAC Imaging of the Brain. ACS Chem. Neurosci. (2015) 6:705-715. PMCID: PMC4439341.

 

26.    Wang C, Schroeder FA, Wey HY, Borra R, Wagner FF, Reisa S, Kim SW, Haggarty SJ, Holson EB, Hooker JM. Imaging HDAC expression in brain and major peripheral organs using [11C]Martinostat. J. Med. Chem. (2014) 57:7999-8009. PMCID: PMC4191584

 

27.    Schroeder FA, Wang C, Van de Bittner G, Neelamegam R, Takakura R, Karunakaran P, Wey HY, Gale J, Zhang YL, Holson E, Haggarty S, Hooker JM. PET imaging demonstrates HDAC target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. ACS Chem. Neurosci. (2014) 5:1055-62. PMCID: PMC4198064

 

28.    Wey HY, Catana C, Hooker JM, Dougherty DD, Knudsen GM, Wang DJ, Rosen BR, Gollub RL, Kong J. Simultaneous fMRI-PET Imaging of the Opioidergic Pain System in Human Brain. NeuroImage. (2014) 102:275-282. PMCID: PMC4348014

 

29.    Rotstein BH, Wey HY, Shoup TM, Wilson AA, Liang SH, Hooker JM, Vasdev N. PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Non-Human Primates. Mol. Pharm. (2014) 11:3832-8. PMCID: PMC4224570

 

30.    Villien M, Wey HY, Mandeville JB, Catana C, Polimeni JR, Sander CY, Zürcher NR, Chonde DB, Fowler JS, Rosen BR, Hooker JM. Dynamic Functional Imaging of Brain Glucose Utilization using fPET-FDG. NeuroImage. (2014) 100:192-9. PMCID: PMC4224310

 

31.    Ren H, Wey HY, Strebl M, Neelamegam R, Ritter T, Hooker JM. Synthesis and Imaging Validation of [18F]MDL100907 Enabled by Ni-mediated Fluorination. ACS Chem. Neurosci. (2014) 5:611-5. PMCID: PMC4102961

 

32.    Wey HY, Phillips KA, McKay DR, Laird AR, Kochunov P, Davis MD, Glahn DC, Duong TQ, Fox PT. Multi-Region Hemispheric Specialization Differentiates Human from Nonhuman Primate Brain Function. Brain Structure and Function. (2014) 219:2187-94. PMCID: PMC4219928

 

33.    Kong J, Spaeth RB, Wey HY, Cheetham A, Cook AH, Jensen KB, Tan Y, Liu H, Wang D, Loggia ML, Napadow V, Smoller JW, Wasan A, Gollub RL. S1 is associated with chronic low back pain: a functional and structural MRI study. Mol Pain. (2013) 9:43. PMCID: PMC3765748

 

34.    Kong J, Jensen KB, Loiotile R, Cheetham A, Wey HY, Tan Y, Rosen BR, Smoller JW, Kaptchuk TJ, Gollub RL. Resting state function connectivity is associated with predictive cue modulatory effects on pain. Pain. (2013) 154:459-67. PMCID: PMC3725961

 

35.    Wey HY, Desai VR, Duong TQ. A Review of Current Imaging Methods Used in Stroke Research. Neurol. Res. (2013) 35:1092-102. PMCID: PMC4116097

 

36.    Wey HY and Duong TQ. Multimodal MRI of Nonhuman Primate Stroke. Transl. Stroke Res. (2012) 3:84–89.

 

37.    Wey HY, Kroma GM, Li J, Leland MM, Jones L, Duong TQ. MRI of Perfusion-Diffusion Mismatch in Non-human Primate (Baboon) Stroke: A Preliminary Report. Open Neuroimag J. (2011) 5:147-52. PMCID: PMC3257583

 

38.    Salinas FS, Szabób CA, Zhang W, Jones L, Leland MM, Wey HY, Duong TQ, Fox PT, Narayan S. Functional neuroimaging of the baboon during concurrent image-guided transcranial magnetic stimulation. NeuroImage (2011) 57:1393-401. PMCID: PMC3139451

 

39.    Zhang Y*, Wey HY*, San Emeterio Nateras O, Peng Q, Duong TQ. Anatomical, BOLD, and Blood Flow MRI of Large Non-human Primate (Baboon) Retina. Magn. Reson. Med. (2011) 66:546-54. PMCID: PMC3561722 (*equal contribution)

 

40.    Shih YYI, Wey HY, De La Garza BH, Duong TQ. Striatal and Cortical BOLD, Blood Flow, Blood Volume, Oxygen Consumption, and Glucose Consumption Changes in Noxious Forepaw Electrical Stimulation. J. Cereb. Blood Flow Metab. (2011) 31:832-41. PMCID: PMC3063626

 

41.    Wey HY, Wang DJ, Duong TQ. Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of Visual and Vibrotactile Stimulations in Baboons. J. Cereb. Blood Flow Metab (2011) 31:715-24. PMCID: PMC3049525

 

42.    Kochunov P, Castro C, Davis MD, Dudley D, Wey HY, Purdy D, Fox PT, Simerly C, Schatten G. Fetal Brain during a Binge Drinking Episode - A Dynamic Susceptibility Contrast Fetal Brain Perfusion Study. NeuroReport (2010) 10:716-21. PMCID: PMC2898126

 

43.    Wey HY, Li J, Szabo CA, Fox PT, Leland MM, Jones L, Duong TQ. BOLD fMRI of Visual and Somatosensory-motor Stimulations in Baboons. NeuroImage (2010) 52:1420-7. PMCID: PMC2949958